Profile of liver cholestatic biomarkers following prolonged ketamine administration in patients with COVID-19.

BACKGROUND: To investigate the possible influence of prolonged ketamine (K) or esketamine (ESK) infusion on the profile of liver cholestatic biomarkers in patients with COVID-19 infection. METHODS: A retrospective analysis was performed on 135 patients with COVID-19 related ARDS who received prolonged K or ESK infusion. They were compared to 15 COVID-19 ICU patients who did not receive K/ESK while being mechanically ventilated and 108 COVID-19 patients who did not receive mechanical ventilation nor K/ESK. The profile of the liver function tests was analysed in the groups. RESULTS: Peak values of ALP, GGT and bilirubin were higher in the K/ESK group, but not for AST and ALT. Peak values of ALP were significantly higher among patients who underwent mechanical ventilation and who received K/ESK, compared with mechanically ventilated patients who did not receive K/ESK. There was a correlation between these peak values and the cumulative dose and duration of K/ESK therapy. CONCLUSIONS: Based on the observations of biliary anomalies in chronic ketamine abusers, prolonged exposure to ketamine sedation during mechanical ventilation may also be involved, in addition to viral infection causing secondary sclerosing cholangitis. The safety of prolonged ketamine sedation on the biliary tract requires further investigations.

Nephrogenic Diabetes Insipidus following an Off-Label Administration of Sevoflurane for Prolonged Sedation in a COVID-19 Patient and Possible Influence on Aquaporin-2 Renal Expression.

During the recent COVID-19 pandemic, the rapidly progressive shortage of intravenous sedative drugs led numerous intensive care units to look for potential alternatives in patients requiring mechanical ventilation for severe acute respiratory distress syndrome (ARDS). Inhalational sedation using the AnaConDa® device for sevoflurane administration is a possible option. In a 54-year-old COVID-19 patient with severe ARDS requiring extracorporeal membranous oxygenation (ECMO), sevoflurane on AnaConDa® device was administered for 8 days but was complicated by the development of nephrogenic diabetes insipidus (NDI). Other causes of NDI or central diabetes insipidus were reasonably excluded, as in other previously published cases of NDI in ICU patients receiving prolonged sevoflurane-based sedation. In addition, the postmortem examination suggested a lower expression of aquaporin-2 in renal tubules. This observation should prompt further investigations to elucidate the role of aquaporin-2 in sevoflurane-related NDI. Inhaled isoflurane sedation is a possible alternative.

How to manage cigarette smoking in kidney transplant candidates and recipients?

Tobacco smoking is a frequent problem affecting many kidney transplant (KT) candidates and recipients. The negative impact of active smoking on KT outcomes has been demonstrated. Consequently, most guidelines strongly recommend quitting smoking before considering kidney transplantation. However, nicotine addiction is a complex multifactorial disease and only 3-5% of the patients who try to quit by themselves achieve prolonged abstinence. Smoking cessation programmes (SCPs) have proven their efficacy in the general population to increase the rate of quitting and should therefore be proposed to all smoking KT candidates and recipients. Nevertheless, SCPs have not been evaluated in the KT field and not all KT centres have easy access to these programmes. In this work, we aim to review the current knowledge on the subject and provide an overview of the available interventions to help smoking patients quit. We detail non-pharmaceutical and pharmaceutical approaches and discuss their use in KT candidates and recipients.

[The reasons for refusal and abandonment of treatment in the emergency surgery at the University Hospital Center of Bouake, Ivory Coast]. / Les raisons du refus et abandon de soins aux urgences chirurgicales du Centre Hospitalier et Universitaire de Bouaké, Côte d'Ivoire.

The refusal and abandonment of treatment is a behavior frequently observed in our daily practice. The purpose of this study was to describe the epidemiology and to identify the reasons for refusals and abandonment of treatment. We conducted a prospective study in the emergency surgery at the University Hospital Center of Bouake from 1st January 2018 to 31st December 2018. It involved all patients admitted with traumatic lesions who had refused or abandoned treatment. Data from 106 cases (16%) of refusal and abandonment of treatment out of 662 cases admitted with limb traumas were examined over this period. The average age of patients was 37 years. The study enrolled 77 men (72.6%). Tertiary sector workers accounted for 56.6% (n= 60) of cases. Lesions were dominated by closed fractures (82.1%; n= 87) and pelvic limbs were the most achieved (78.3%; n=83). Treatment was based on surgery (n=85; 80.2% ) and orthopaedic treatment (n=21; 19.8%). The cost of orthopedic treatment was estimated at 26 500 CFA francs (40 euros) while at 250 000 FCFA (380 euros) for surgical treatment. These costs varied as a function of implant prescribed and its location. Refusal of tratment was expressed by patients (n=30; 28.3%) and by parents (n=76; 71.7%). Reported reasons were dominated by financial problems (n=62; 58.5%), trust in traditional medicine (n=42; 39.6%), religious belief (n=2; 1.9%). The average time of refusal was 22 hours. Eighty eight point seven percent (n=94) of patients signed discharge while 11.3% (n=12) escaped. Refusal of care is a recurrent theme in our context and is due to inadequate health care management of people with limited financial resources.

[Fractures of the pelvis causing vaginal wound]. / Fractures du bassin occasionnant une plaie du vagin.

Pelvic fractures occur most often in people experiencing a traumatic event. Although they are due to high-velocity injuries, these lesions are rarely associated with vaginal wounds, and data on patients' evolution are scarce. The purpose of our study was to describe anatomoclinic lesions, treatment and progression of these lesions. The study involved five female patients who had had vaginal wounds due to pelvic fracture over the past decade. The patients had a mean age of 23,6 years. Vaginal wounds were mainly due to road accidents. Two patients had linear wounds and three had lacerated wounds. Vaginal suture was performed in all patients. After a mean follow-up period of 2 years, patients' evolution was favorable with healing of vaginal wound and bone. Genital and obstetric functions were not compromised. Although vaginal wounds most often go unnoticed, they should be suspected in female patients with pelvic fracture.

Surgical mask on top of high-flow nasal cannula improves oxygenation in critically ill COVID-19 patients with hypoxemic respiratory failure.

OBJECTIVE: Critically ill patients admitted in ICU because of COVID-19 infection display severe hypoxemic respiratory failure. The Surviving Sepsis Campaign recommends oxygenation through high-flow nasal cannula over non-invasive ventilation. The primary outcome of our study was to evaluate the effect of the addition of a surgical mask on a high-flow nasal cannula system on oxygenation parameters in hypoxemic COVID-19 patients admitted in ICU who do not require urgent intubation. The secondary outcomes were relevant changes in PaCO2 associated with clinical modifications and patient's feelings. DESIGN: We prospectively assessed 21 patients admitted in our mixed Intensive Care Unit of the Cliniques Universitaires Saint Luc. MAIN RESULTS: While FiO2 was unchanged, we demonstrate a significant increase of PaO2 (from 59 (± 6), to 79 mmHg (± 16), p < 0.001), PaO2/FiO2 from 83 (± 22), to 111 (± 38), p < 0.001) and SaO2 (from 91% (± 1.5), to 94% (± 1.6), p < 0.001), while the patients were under the surgical mask. The SpO2 returned to pre-treatment values when the surgical mask was removed confirming the effect of the device rather than a spontaneous positive evolution. CONCLUSION: A surgical mask placed on patient's face already treated by a High-flow nasal cannula device improves COVID-19 patient's oxygenation admitted in Intensive Care Unit for severe hypoxemic respiratory failure without any clinically relevant side.

Emerging Concepts and Applied Machine Learning Research in Patients with Drug-Induced Repolarization Disorders.

The paper presents a review of current research to develop predictive models for automated detection of drug-induced repolarization disorders and shows a feasibility study for developing machine learning tools trained on massive multimodal datasets of narrative, textual and electrocardiographic records. The goal is to reduce drug-induced long QT and associated complications (Torsades-de-Pointes, sudden cardiac death), by identifying prescription patterns with pro-arrhythmic propensity using a validated electronic application for the detection of adverse drug events with data mining and natural language processing; and to compute individual-based predictive scores in order to further identify clinical conditions, concomitant diseases, or other variables that correlate with higher risk of pro-arrhythmic situations.

Evaluation of Document Retrieval Systems on a Medical Corpus in French: Indexation vs. Feature Learning.

This paper presents five document retrieval systems for a small (few thousands) and domain specific corpora (weekly peer-reviewed medical journals published in French) as well as an evaluation methodology to quantify the models performance. The proposed methodology does not rely on external annotations and therefore can be used as an ad hoc evaluation procedure for most document retrieval tasks. Statistical models and vector space models are empirically compared on a synthetic document retrieval task. For our dataset size and specificities the statistical approaches consistently performed better than its vector space counterparts.

Adaptive Time-Dependent Priors and Bayesian Inference to Evaluate SARS-CoV-2 Public Health Measures Validated on 31 Countries.

With the rapid spread of the SARS-CoV-2 virus since the end of 2019, public health confinement measures to contain the propagation of the pandemic have been implemented. Our method to estimate the reproduction number using Bayesian inference with time-dependent priors enhances previous approaches by considering a dynamic prior continuously updated as restrictive measures and comportments within the society evolve. In addition, to allow direct comparison between reproduction number and introduction of public health measures in a specific country, the infection dates are inferred from daily confirmed cases and confirmed death. The evolution of this reproduction number in combination with the stringency index is analyzed on 31 European countries. We show that most countries required tough state interventions with a stringency index equal to 79.6 out of 100 to reduce their reproduction number below one and control the progression of the pandemic. In addition, we show a direct correlation between the time taken to introduce restrictive measures and the time required to contain the spread of the pandemic with a median time of 8 days. This analysis is validated by comparing the excess deaths and the time taken to implement restrictive measures. Our analysis reinforces the importance of having a fast response with a coherent and comprehensive set of confinement measures to control the pandemic. Only restrictions or combinations of those have shown to effectively control the pandemic.

Use and Understanding of Anonymization and De-Identification in the Biomedical Literature: Scoping Review.

BACKGROUND: The secondary use of health data is central to biomedical research in the era of data science and precision medicine. National and international initiatives, such as the Global Open Findable, Accessible, Interoperable, and Reusable (GO FAIR) initiative, are supporting this approach in different ways (eg, making the sharing of research data mandatory or improving the legal and ethical frameworks). Preserving patients' privacy is crucial in this context. De-identification and anonymization are the two most common terms used to refer to the technical approaches that protect privacy and facilitate the secondary use of health data. However, it is difficult to find a consensus on the definitions of the concepts or on the reliability of the techniques used to apply them. A comprehensive review is needed to better understand the domain, its capabilities, its challenges, and the ratio of risk between the data subjects' privacy on one side, and the benefit of scientific advances on the other. OBJECTIVE: This work aims at better understanding how the research community comprehends and defines the concepts of de-identification and anonymization. A rich overview should also provide insights into the use and reliability of the methods. Six aspects will be studied: (1) terminology and definitions, (2) backgrounds and places of work of the researchers, (3) reasons for anonymizing or de-identifying health data, (4) limitations of the techniques, (5) legal and ethical aspects, and (6) recommendations of the researchers. METHODS: Based on a scoping review protocol designed a priori, MEDLINE was searched for publications discussing de-identification or anonymization and published between 2007 and 2017. The search was restricted to MEDLINE to focus on the life sciences community. The screening process was performed by two reviewers independently. RESULTS: After searching 7972 records that matched at least one search term, 135 publications were screened and 60 full-text articles were included. (1) Terminology: Definitions of the terms de-identification and anonymization were provided in less than half of the articles (29/60, 48%). When both terms were used (41/60, 68%), their meanings divided the authors into two equal groups (19/60, 32%, each) with opposed views. The remaining articles (3/60, 5%) were equivocal. (2) Backgrounds and locations: Research groups were based predominantly in North America (31/60, 52%) and in the European Union (22/60, 37%). The authors came from 19 different domains; computer science (91/248, 36.7%), biomedical informatics (47/248, 19.0%), and medicine (38/248, 15.3%) were the most prevalent ones. (3) Purpose: The main reason declared for applying these techniques is to facilitate biomedical research. (4) Limitations: Progress is made on specific techniques but, overall, limitations remain numerous. (5) Legal and ethical aspects: Differences exist between nations in the definitions, approaches, and legal practices. (6) Recommendations: The combination of organizational, legal, ethical, and technical approaches is necessary to protect health data. CONCLUSIONS: Interest is growing for privacy-enhancing techniques in the life sciences community. This interest crosses scientific boundaries, involving primarily computer science, biomedical informatics, and medicine. The variability observed in the use of the terms de-identification and anonymization emphasizes the need for clearer definitions as well as for better education and dissemination of information on the subject. The same observation applies to the methods. Several legislations, such as the American Health Insurance Portability and Accountability Act (HIPAA) and the European General Data Protection Regulation (GDPR), regulate the domain. Using the definitions they provide could help address the variable use of these two concepts in the research community.

La fasciite nécrosante des membres dans un service de chirurgie plastique en milieu tropical

Introduction: La fasciite nécrosante est une urgence chirurgicale et médicale. Cette étude avait pour objectif de décrire le profil épidémiologique, clinique, et thérapeutique des patients ayant une fasciite nécrosante dans un service de chirurgie plastique en milieu tropical. Méthodes : il s'agissait d'une étude rétrospective descriptive de dossiers des patients traités pour une fasciite nécrosante entre janvier 2015 et décembre 2017. Les paramètres d'étude concernaient l'épidémiologie, les signes, le traitement et l'évolution. Les lésions cutanées ont été classées selon les critères de Wong. Le score LRINEC a été établi. Résultats : Sur la période d'étude, 947 patients ont été reçus. Dix-huit avaient une fasciite nécrosante soit 1.9% des patients. Cette étude a concerné 11patients. Il y avait neuf femmes et deux hommes. L'âge moyen était de 47 ans. Tous les patients avaient un faible revenu économique. Une porte d'entrée était notée (n=8). Les pathologies médicales commorbides associées étaient le diabète (n=5), l'infection au VIH (n=2) . La prise d'anti-inflammatoires non stéroïdiens a été noté (n=5). L'usage de cataplasmes était enregistré (n= 8). La notion de prise d'alcool a été notée (n=2). Le délai moyen de consultation était de 29 jours. Les lésions siégeaient au membre inférieur ( n=9) et au membre supérieur (n=2). Le diagnostic était clinique. Les lésions étaient du stade 3. Le score LRINEC a été établi chez huit patients. Il était inférieur à 6 (n=4), égal à 6 (n=2), supérieur ou égal à 8(n=2). Le traitement médical comportait la ceftriaxone associée au métronidazole. Une excision des tissus nécrosés a été faite dans les 24 heures suivant l'admission. Une greffe de peau mince a été réalisée dans un délai moyen de 28,7 jours. Un décès a été enregistré (patiente atteint du VIH avec score LRINEC=13). Au recul moyen de 14 mois il n'y avait pas de récidive. Conclusion : La fasciite nécrosante est rare. Les lésions ont intéressé en général des patients de sexe féminin avec un âge moyen de 47ans. Ils avaient des pathologies médicales commorbides associées à des degrés variables. Le traitement traditionnel à type de cataplasme est un facteur favorisant. La consultation est tardive. Les lésions concernaient les membres inferieurs dans la majorité des cas. Elles étaient de stade 3. Une excision des tissus nécrosés et une greffe de peau mince après la formation d'une granulation ont été faites. Le traitement médical comportait la ceftriaxone associée au métronidazole. Un décès a été noté. Au recul moyen de 14 mois il n'y avait pas de récidives

[Bigdata, artificial intelligence and blockchain for dummies]. / BigData, intelligence artificielle, blockchain : guide pratique.

Digitalization is transforming every aspect of life, it is also transforming deeply medicine. The digitalization era is characterized by a large production of new data streams while existing processes are progressively migrated, such as writing or imaging. The very large and fast-growing amount of data available requires new storage, transport and analytical tools. This paper presents some of them, such as natural language processing, artificial intelligence, and graph databases. A short introduction to the technology of blockchain is also provided, as it is increasingly used in some non-monetary transaction in medicine, such as data exchanges and consent management.

La société en général, la médecine en particulier, sont emportées par la vague de la digitalisation. Ce phénomène s'appuie sur une production d'immenses quantités de données, parfois du fait de la dématérialisation de processus, comme l'écriture ou la photographie, parfois du fait de l'acquisition de nouvelles données, comme la géolocalisation. Ceci nécessite de nouveaux instruments pour le transport, le stockage et le traitement de l'information. Cet article présente quelques enjeux et instruments utilisés, telles les techniques de traitement du langage naturel, de l'intelligence artificielle et des bases de données en graphes. Enfin, nous décrivons brièvement la technologie de la blockchain, qui est de plus en plus proposée en médecine pour des processus non monétaires, tels que l'échange de données ou la gestion du consentement.

[Secondary amputation of the limb after primary surgery of open fractures of the lower limb]. / Amputations secondaires du membre après une chirurgie primaire des fractures ouvertes du membre inferieur.

This study reports the complications occurred during the management of open fractures of the lower limbs, resulting in secondary amputations, observed in clinicians' practice in recent years as well as different risk factors and possible deficiencies in management at the origin of these complications. We conducted a retrospective study over a period of 06 years (January 2006 - January 2012). It included patients with open fracture of the lower limb initially treated in our institution and whose complications resulted in amputation. All patient undergoing emergency amputation after examination at the Emergency Department were excluded. All patient treated in another hospital before being referred to us were excluded by the study, even if secondary amputation had been performed in our institution. We collected data by analyzing the records of patients (clinical and complementary examinations, surgical reports). We evaluated our management of open fractures of the lower limb according to the guidelines and recommendations found in the literature. These complications were observed in 9 out of 306 open fractures of the lower limb treated in the same period (January 2006 - January 2012), reflecting a rate of 2.9%. The average age was 42.6(26-57) years, all patients were male. We recorded 1 case of fracture of the femur, 7 cases of fracture of 2 leg bones and 1 case of foot crushing. These were open fractures including 1 case of type 1 fracture, 3 cases of type II fracture and 5 cases of type III fracture, according to Gustilo and Anderson classification. We performed 5 amputations of the thigh and 4 amputation of the upper third of the leg. Various complications motivated these amputations, including bone infections or soft-tissue gangrenes of ischemic or infectious origin. The patients had no morbidities such as diabete and were not chronic smokers. No patient died. Open fractures deserve special attention of the surgeon on immediade complications both from a diagnostic and therapeutic point of view in order to reduce the amputation rates after primary surgery giving patients the impression that they had an incorrect procedure performed on them. Particular attention should be paid to the degree of initial contamination and to the presence of a virulent germ at the site of trauma which may motivate particular attitudes during primary management.